モリナガ　アキノリ   森永　明倫    所属   医学部 医学科（附属東洋医学研究所）    職種   助教
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Good Rehabilitation Outcomes and Improved Nutritional Status After Treatment With the Japanese Herbal Medicine Ninjin'yoeito in an Elderly Patient With Hip Fracture and Sarcopenia: A Case Report.
掲載誌名	正式名：Frontiers in nutrition 略　 称：Front Nutr ISSNコード：2296861X/2296861X
掲載区分	国外
巻・号・頁	7,pp.85
著者・共著者	Morinaga Akinori†, Nakamura Hiroki, Hattanmaru Kenji, Rokot Natasya Trivena, Kimura Yoko, Ito Takashi
担当区分	筆頭著者,責任著者
発行年月	2020
概要	We report a case involving a 92-year-old man who successfully received treatment with ninjin'yoeito, a Japanese herbal medicine, during the rehabilitation phase after hip fracture surgery. The patient was diagnosed with a left femoral neck fracture and underwent surgery. Two weeks after surgery, he was admitted to a rehabilitation hospital. At that time, his height, weight, body fat percentage, muscle mass, and Functional Independence Measure (FIM) score were 167 cm, 61 kg, 34.1%, 38.2 kg, and 49, respectively. For 1 month after surgery (i.e., 2 weeks after admission to the rehabilitation facility), he received rikkunshito, a traditional Japanese herbal medicine also known as Kampo medicine, for appetite loss and underwent rehabilitation. However, his appetite loss showed no improvement, and rikkunshito (7.5 g/d) was replaced with ninjin'yoeito (7.5 g/d). Two months later, although the patient's body weight and body fat percentage decreased to 56.5 kg and 21.1%, respectively, his muscle mass increased to 38.9 kg. Nutritional status evaluation indicated an improvement in the level of proteins such as transferrin, prealbumin, and retinol-binding protein, which reflected an increase in food intake. The FIM score improved from 49 to 105. No side effects were observed. The findings from this case suggest that ninjin'yoeito, which includes Astragalus root and Schisandra fruit, may be an effective treatment option for sarcopenia or frailty with appetite loss and impaired activities of daily living in aged patients.
DOI	10.3389/fnut.2020.00085
PMID	32714940