モリナガ　アキノリ   森永　明倫    所属   医学部 医学科（附属東洋医学研究所）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4.
掲載誌名	正式名：Drug design, development and therapy 略　 称：Drug Des Devel Ther ISSNコード：11778881/11778881
掲載区分	国外
巻・号・頁	10,pp.2193-202
著者・共著者	Runtuwene Joshua, Cheng Kai-Chun, Asakawa Akihiro, Amitani Haruka, Amitani Marie, Morinaga Akinori, Takimoto Yoshiyuki, Kairupan Bernabas Harold Ralph, Inui Akio
発行年月	2016
概要	BACKGROUND:Rosmarinic acid (RA) is a natural substance that may be useful for treating diabetes mellitus. The present study investigated the effects of RA on glucose homeostasis and insulin regulation in rats with streptozocin (STZ)-induced type 1 diabetes or high-fat diet (HFD)-induced type 2 diabetes.METHODS:Glucose homeostasis was determined using oral glucose tolerance tests and postprandial glucose tests, and insulin activity was evaluated using insulin tolerance tests and the homeostatic model assessment for insulin resistance. Additionally, the protein expression levels of PEPCK and GLUT4 were determined using Western blot analysis.RESULTS:RA administration exerted a marked hypoglycemic effect on STZ-induced diabetic rats and enhanced glucose utilization and insulin sensitivity in HFD-fed diabetic rats. These effects of RA were dose-dependent. Meanwhile, RA administration reversed the STZ- and HFD-induced increase in PEPCK expression in the liver and the STZ- and HFD-induced decrease in GLUT4 expression in skeletal muscle.CONCLUSION:RA reduces hyperglycemia and ameliorates insulin sensitivity by decreasing PEPCK expression and increasing GLUT4 expression.
DOI	10.2147/DDDT.S108539
PMID	27462144