井口 成一
     School of Medicine School of Medicine(Tokyo Women's Medical University Hospital)
    
Article types Case report
Language English
Peer review Peer reviewed
Title Higher efficacy of direct hemoperfusion using coated activated-charcoal column for disopyramide poisoning: A case report.
Journal Formal name:Medicine
Abbreviation:Medicine (Baltimore)
ISSN code:(1536-5964)0025-7974(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 96(49),pp.e8755
Author & co-author Iguchi Shigekazu, Yamaguchi Naotaka, Takami Hiroki, Komatsu Takayuki, Ookubo Hirokazu, Sekii Hajime, Inoue Kenji, Okazaki Shinya, Okai Iwao, Maruyama Sonomi, Nomura Tomohisa, Sugita Manabu
Publication date 2017/12
Summary Because disopyramide has low molecular weight and a small distribution volume, blood purification is considered to be the most effective therapy. We selected direct hemoperfusion for relatively high protein-binding rate. In fact, clinical status was dramatically improved, and the calculated half-life of the direct hemoperfusion phase was the shortest of all phases. In cases of severe or life-threatening disopyramide poisoning, blood purification therapy including direct hemoperfusion using a coated activated-charcoal column should be performed.
DOI 10.1097/MD.0000000000008755
PMID 29245231