井口 成一
     School of Medicine School of Medicine(Tokyo Women's Medical University Hospital)
    
Article types Original article
Language English
Peer review Peer reviewed
Title Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination.
Journal Formal name:PloS one
Abbreviation:PLoS One
ISSN code:(1932-6203)1932-6203(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 11(5),pp.e0155512
Author & co-author Iguchi Shigekazu, Mizutani Tomonori, Hiramatsu Keiichi, Kikuchi Ken
Publication date 2016
Summary Hypermutation and homologous recombination of the ribosomal RNA genes, including 23S rRNA genes, appear not to have been sources of the accelerated acquisition of linezolid resistance observed in our clinical case. Increased frequency of short sequence recombination may have resulted from a recQ variant in the infecting organism.
DOI 10.1371/journal.pone.0155512
PMID 27182700