|
OMORI Teppei
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position |
|
| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Association of ulcerative colitis symptom severity and proctocolectomy with multidimensional patient-reported outcomes: a cross-sectional study |
| Journal | Formal name：Journal of gastroenterology Abbreviation：J Gastroenterol ISSN code：14355922/09441174 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 58(8),pp.751-765 |
| Author and coauthor | MATSUOKA Katsuyoshi,YAMAZAKI Hajime,NAGAHORI Masakazu,KOBAYASHI Taku,OMORI Teppei,MIKAMI Yohei,FUJII Toshimitsu,SHINZAKI Shinichiro,SARUTA Masayuki,MATSUURA Minoru,YAMAMOTO Takayuki,MOTOYA Satoshi,HIBI Toshifumi,WATANABE Mamoru, Fernandez Jovelle,FUKUHARA Shunichi,HISAMATSU Tadakazu |
| Publication date | 2023/08 |
| Summary | BACKGROUND:The YOu and Ulcerative colitis: Registry and Social network (YOURS) is a large-scale, multicenter, patient-focused registry investigating the effects of lifestyle, psychological factors, and clinical practice patterns on patient-reported outcomes in patients with ulcerative colitis in Japan. In this initial cross-sectional baseline analysis, we comprehensively explored impacts of symptom severity or proctocolectomy on nine patient-reported outcomes.METHODS:Patients receiving tertiary care at medical institutions were consecutively enrolled in the YOURS registry. The patients completed validated questionnaires on lifestyle, psychosocial factors, and disease-related symptoms. Severity of symptoms was classified with self-graded stool frequency and rectal bleeding scores (categories: remission, active disease [mild, moderate, severe]). The effects of symptom severity or proctocolectomy on nine scales for quality of life, fatigue, anxiety/depression, work productivity, and sleep were assessed by comparing standardized mean differences of the patient-reported outcome scores.RESULTS:Of the 1971 survey responses analyzed, 1346 (68.3%) patients were in remission, 583 (29.6%) had active disease, and 42 (2.1%) had undergone proctocolectomy. A linear relationship between increasing symptom severity and worsening quality of life, fatigue, anxiety, depression, and work productivity was observed. Patients with even mild symptoms had worse scores than patients in remission. Patients who had undergone proctocolectomy also had worse scores than patients in remission.CONCLUSIONS:Ulcerative colitis was associated with reduced mood, quality of life, fatigue, and work productivity even in patients with mild symptoms, suggesting that management of active ulcerative colitis may improve patient-reported outcomes irrespective of disease severity. (UMIN Clinical Trials Registry: UMIN000031995, https://www.umin.ac.jp/ctr/index-j.htm ). |
| DOI | 10.1007/s00535-023-02005-7 |
| PMID | 37351647 |