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ARASHIKI Nobuto
Department School of Medicine, School of Medicine Position Assistant Professor |
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| Article types | Review article |
| Language | English |
| Peer review | Peer reviewed |
| Presence of invitation | Invited paper |
| Title | Maintenance and regulation of asymmetric phospholipid distribution in human erythrocyte membranes: implications for erythrocyte functions. |
| Journal | Formal name：Current opinion in hematology Abbreviation：Curr Opin Hematol ISSN code：(15317048)10656251(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 24(3),pp.167-172 |
| Author and coauthor | Arashiki Nobuto, Takakuwa Yuichi |
| Authorship | Lead author |
| Publication date | 2017/05 |
| Summary | For survival, phosphatidylserine surface exposure is prevented by cholesterol-mediated suppression of PLSCR1 under low Ca concentrations, irrespective of flipping by ATP11C. In senescent erythrocytes, PLSCR1 is activated by elevated Ca, resulting in phosphatidylserine exposure, allowing macrophage phagocytosis. These recent molecular findings establish the importance of the maintenance and regulation of phosphatidylserine distribution for both the survival and death of human erythrocytes. |
| DOI | 10.1097/MOH.0000000000000326 |
| PMID | 28118222 |