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アラシキ ノブト
ARASHIKI Nobuto
新敷 信人 所属 医学部 医学科 職種 助教 |
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| 論文種別 | 総説 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 招待の有無 | 招待あり |
| 表題 | Maintenance and regulation of asymmetric phospholipid distribution in human erythrocyte membranes: implications for erythrocyte functions. |
| 掲載誌名 | 正式名：Current opinion in hematology 略 称：Curr Opin Hematol ISSNコード：(15317048)10656251(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 24(3),pp.167-172 |
| 著者・共著者 | Arashiki Nobuto, Takakuwa Yuichi |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2017/05 |
| 概要 | For survival, phosphatidylserine surface exposure is prevented by cholesterol-mediated suppression of PLSCR1 under low Ca concentrations, irrespective of flipping by ATP11C. In senescent erythrocytes, PLSCR1 is activated by elevated Ca, resulting in phosphatidylserine exposure, allowing macrophage phagocytosis. These recent molecular findings establish the importance of the maintenance and regulation of phosphatidylserine distribution for both the survival and death of human erythrocytes. |
| DOI | 10.1097/MOH.0000000000000326 |
| PMID | 28118222 |