Yukiko Niwa    Department   School of Medicine(Yachiyo Medical Center), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Preoperative six-minute walk distance as a predictor of postoperative complication in patients with esophageal cancer.
Journal	Formal name：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus Abbreviation：Dis Esophagus ISSN code：14422050/11208694
Domestic / Foregin	Foregin
Volume, Issue, Page	33(2),pp.*-*
Author and coauthor	Inoue Takayuki, Ito Satoru, Kanda Mitsuro, Niwa Yukiko, Nagaya Motoki, Nishida Yoshihiro, Hasegawa Yoshinori, Koike Masahiko, Kodera Yasuhiro
Publication date	2020/03
Summary	Surgery for esophageal cancer is associated with high morbidity and mortality. Reduced pulmonary functions and exercise capacity are known as risk factors for complications after esophagectomy. The 6-minute walk distance (6MWD) measured by the 6-minute walk test (6MWT) is a simple field test that can be used to evaluate the functional exercise capacity of patients who undergo thoracic surgery. The aim of this study was to evaluate the association of the preoperative 6MWD with postoperative complications in patients with esophageal cancer. Records of a total of 111 patients who underwent thoracic surgery followed by postoperative rehabilitation from January 2013 to December 2015 were retrospectively reviewed. Data of patients who experienced Clavien-Dindo grade II or severer (grade ≥ II) complications were compared with those who experienced grade ≤I complications. The 6MWD was significantly correlated with age, serum albumin concentration, hemoglobin concentration, and hand grip strength. A total of 42 patients experienced grade ≥II. The 6MWD of patients with grade ≥ II complications was significantly shorter than that of those with grade ≤I complications. In receiver operating characteristic analysis, 6MWD ≤ 454 m was a threshold for predicting grade ≥II complications with 71.0% sensitivity and 54.8% specificity. The incidence of grade ≥II complications led to delayed ambulation and longer stays in hospital. In the multiple regression analysis, the preoperative risk factors for incidence of grade ≥II complications included lower levels of preoperative 6MWD and % of the predicted value of forced expiratory volume in 1 second. Our results indicate that the 6MWT is useful to assess preoperative physical status in patients with esophageal cancer.
DOI	10.1093/dote/doz050
PMID	31111872