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Yukiko Niwa
Department School of Medicine(Yachiyo Medical Center), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Epithelial to mesenchymal transition correlates with tumor budding and predicts prognosis in esophageal squamous cell carcinoma. |
| Journal | Formal name：Journal of surgical oncology Abbreviation：J Surg Oncol ISSN code：10969098/00224790 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 110(6),pp.764-9 |
| Author and coauthor | Niwa Yukiko, Yamada Suguru, Koike Masahiko, Kanda Mitsuro, Fujii Tsutomu, Nakayama Goro, Sugimoto Hiroyuki, Nomoto Shuji, Fujiwara Michitaka, Kodera Yasuhiro |
| Publication date | 2014/11 |
| Summary | BACKGROUND AND OBJECTIVES:Epithelial to mesenchymal transition (EMT) is considered to play an important role in cancer invasion. Tumor budding is a prognostic factor in esophageal squamous cell carcinoma (ESCC). The aim of this study was to explore the correlation between EMT and tumor budding.METHODS:Surgical specimens from 78 cases of ESCC resected without preoperative treatment between 2001 and 2013 were enrolled in the study. The mRNA expressions of E-cadherin and vimentin were measured in cancerous tissues using real-time PCR, and each tumor was classified into either epithelial or mesenchymal group. Tumor budding was evaluated in H&E-stained slides and divided into two groups; low-grade budding (<3) and high-grade budding (≥3).RESULTS:The 5-year survival rate in the epithelial group was significantly higher than that in the mesenchymal group (62.0% vs. 31.5%, P = 0.021). Survival rate of patients in the low-grade budding group was significantly higher than that of patients in the high-grade budding group (75.1% vs. 25.9%, P < 0.001). High-grade tumor budding was significantly associated with the mesenchymal group (P = 0.009).CONCLUSION:EMT was found to occur in ESCC and was significantly associated with tumor budding. Tumor budding was identified as a significant independent prognostic factor among the current population of ESCC. |
| DOI | 10.1002/jso.23694 |
| PMID | 24975035 |