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JUJO Kentaro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Review article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Alternative Exercise Intervention for Patients With Severe Peripheral Artery Disease - Akt1-Induced Blood Flow Recovery. |
| Journal | Formal name：Circulation journal : official journal of the Japanese Circulation Society Abbreviation：Circ J ISSN code：1346-9843/1347-4820 |
| Domestic / Foregin | Domestic |
| Publisher | The Japanese Circulation Society |
| Volume, Issue, Page | 82(11),pp.2705-2706 |
| Author and coauthor | JUJO Kentaro†*, HAGIWARA Nobuhisa |
| Authorship | Lead author,Corresponding author |
| Publication date | 2018/10 |
| Summary | Critical limb ischemia (CLI) is an advanced stage of peripheral artery disease (PAD) and a serious health problem worldwide, even in clinical settings with established endovascular therapy. Currently, the limited therapeutic options cannot overcome the high mortality and morbidity rates of such patients with severe atherosclerotic status. Supervised aerobic exercise therapy is strongly recommended by clinical guidelines and is the most fundamental intervention for patents with PAD. Aerobic exercise induces functional recovery through mechanisms that include hypoxia-induced angiogenic growth factor expression in skeletal muscle1 and endothelial nitric oxide synthase (eNOS) activation by increased shear stress.2 However, performing adequate aerobic exercise is difficult, and the beneficial effects are limited to patients with CLI. In contrast, resistance training has been presented as an alternative exercise intervention for PAD patients. This training aims to maintain and increase muscle volume and can be performed at the bedside even by patients with CLI. |
| DOI | 10.1253/circj.CJ-18-1061 |
| PMID | 30298836 |