ジユウジヨウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Alternative Exercise Intervention for Patients With Severe Peripheral Artery Disease - Akt1-Induced Blood Flow Recovery.
掲載誌名	正式名：Circulation journal : official journal of the Japanese Circulation Society 略　 称：Circ J ISSNコード：1346-9843/1347-4820
掲載区分	国内
出版社	The Japanese Circulation Society
巻・号・頁	82(11),pp.2705-2706
著者・共著者	JUJO Kentaro†*, HAGIWARA Nobuhisa
担当区分	筆頭著者,責任著者
発行年月	2018/10
概要	Critical limb ischemia (CLI) is an advanced stage of peripheral artery disease (PAD) and a serious health problem worldwide, even in clinical settings with established endovascular therapy. Currently, the limited therapeutic options cannot overcome the high mortality and morbidity rates of such patients with severe atherosclerotic status. Supervised aerobic exercise therapy is strongly recommended by clinical guidelines and is the most fundamental intervention for patents with PAD. Aerobic exercise induces functional recovery through mechanisms that include hypoxia-induced angiogenic growth factor expression in skeletal muscle1 and endothelial nitric oxide synthase (eNOS) activation by increased shear stress.2 However, performing adequate aerobic exercise is difficult, and the beneficial effects are limited to patients with CLI. In contrast, resistance training has been presented as an alternative exercise intervention for PAD patients. This training aims to maintain and increase muscle volume and can be performed at the bedside even by patients with CLI.
DOI	10.1253/circj.CJ-18-1061
PMID	30298836