Hisako Nakayama    Department   School of Medicine, School of Medicine    Position   Associate Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive.
Journal	Formal name：Cell Reports Abbreviation：Cell Rep ISSN code：22111247
Domestic / Foregin	Foregin
Volume, Issue, Page	16(4),pp.994-1004
Author and coauthor	MATSUMOTO-MAKIDONO Yoshiko†, NAKAYAMA Hisako, YAMASAKI Miwako, MIYAZAKI Taisuke, WATANABE Masahiko, KANO Masanobu, SAKIMURA Kenji, HASHIMOTO Kouichi*
Authorship	2nd author
Publication date	2016/07
Summary	Some neurons have the ability to enhance output voltage to input current with a preferred frequency, which is called resonance. Resonance is thought to be a basis for membrane potential oscillation. Although ion channels responsible for resonance have been reported, the precise mechanisms by which these channels work remain poorly understood. We have found that resonance is reduced but clearly present in the inferior olivary neurons of Cav3.1 T-type voltage-dependent Ca(2+) channel knockout (KO) mice. The activation of Cav3.1 channels is strongly membrane potential dependent, but less frequency dependent. Residual resonance in Cav3.1 KO mice is abolished by a hyper-polarization-activated cyclic nucleotide-gated (HCN) channel blocker, ZD7288, and is partially suppressed by voltage-dependent K(+) channel blockers. Resonance is inhibited by ZD7288 in wild-type mice and impaired in HCN1 KO mice, suggesting that the HCN1 channel is essential for resonance. The ZD7288-sensitive current is nearly sinusoidal and strongly frequency dependent. These results suggest that Cav3.1 and HCN1 channels act as amplifying and resonating conductances, respectively.
DOI	10.1016/j.celrep.2016.06.053.
PMID	27425615