ナカヤマ ヒサコ   Hisako Nakayama
  中山 寿子
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism.
掲載誌名 正式名:Nature Communications
略  称:Nat Commun
ISSNコード:20411723
掲載区分国外
巻・号・頁 5,5586頁
著者・共著者 PIOCHON Claire†, KLOTH Alexander D, GRASSELLI Giorgio, TITLEY HEATHER K, NAKAYAMA Hisako, HASHIMOTO Kouichi, WAN Vivian, SIMMONS Dana H, EISSA Tahra, NAKATANI Jin, CHERSKOV Adriana, MIYAZAKI Taisuke, WATANABE Masahiko, TAKUMI Toru, KANO Masanobu, WANG Samuel S-H, HANSEL Christian*
発行年月 2014/11
概要 A common feature of autism spectrum disorder (ASD) is the impairment of motor control and learning, occurring in a majority of children with autism, consistent with perturbation in cerebellar function. Here we report alterations in motor behaviour and cerebellar synaptic plasticity in a mouse model (patDp/+) for the human 15q11-13 duplication, one of the most frequently observed genetic aberrations in autism. These mice show ASD-resembling social behaviour deficits. We find that in patDp/+ mice delay eyeblink conditioning--a form of cerebellum-dependent motor learning--is impaired, and observe deregulation of a putative cellular mechanism for motor learning, long-term depression (LTD) at parallel fibre-Purkinje cell synapses. Moreover, developmental elimination of surplus climbing fibres--a model for activity-dependent synaptic pruning--is impaired. These findings point to deficits in synaptic plasticity and pruning as potential causes for motor problems and abnormal circuit development in autism.
DOI 10.1038/ncomms6586
PMID 25418414