Satoru Morita
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Impact of Antibodies That React With Liver Tissue and Donor-Specific Anti-HLA Antibodies in Pediatric Idiopathic Posttransplantation Hepatitis.
Journal Formal name:Transplantation
ISSN code:15346080/00411337
Volume, Issue, Page 101(5),pp.1074-1083
Author and coauthor Hirata Yoshihiro, Yoshizawa Atsushi, Egawa Hiroto, Ueda Daisuke, Okamoto Shinya, Okajima Hideaki, Yurugi Kimiko, Hishida Rie, Hirai Hideyo, Miyagawa-Hayashino Aya, Maekawa Taira, Haga Hironori, Uemoto Sinji
Publication date 2017/05
Summary BACKGROUND:The cause of late graft dysfunction has not been elucidated. Although an antibody-mediated reaction is suspected as a potential mechanism, the target antigens have not been clarified.METHODS:To clarify the etiology of idiopathic posttransplantation hepatitis (IPTH), we simultaneously examined the presence of antibodies that react with liver tissue (ARLT) by means of indirect immunofluorescence staining, as well as the presence of donor-specific anti-human leukocyte antigen antibodies (HLA-DSA). A subanalysis of the IPTH group was also performed. Within the IPTH group, the correlation between ARLT titer and clinical data were analyzed.RESULTS:In the sera of patients with IPTH (30 patients), ARLT were found at a significantly higher frequency than in patients without IPTH (42 patients; P < 0.001). Moreover, the ARLT titer appeared to be correlated with the severity of hepatitis or hepatic injury. In contrast, the frequency of HLA-DSA was significantly lower in patients with IPTH than in patients without IPTH (P = 0.001).CONCLUSION:Our findings indicate that ARLT, and not HLA-DSA, profoundly influence the etiology of IPTH.
DOI 10.1097/TP.0000000000001653
PMID 28118175