Satoru Morita
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Review article
Language Japanese
Peer review Peer reviewed
Presence of invitation Invited paper
Title Pathological Classification of Renal Cell Carcinoma, based on WHO2016 Classification
Domestic / ForeginDomestic
Volume, Issue, Page pp.1427-1438
Author and coauthor Yoji Nagashima, Aya Yamamoto, Reiko Nakajima, Satoru Morita, Hironori Fukuda, Toshio Takagi, Tsunenori Kondo
Publication date 2017/12
Summary Pathological classification of renal cell carcinomas (RCCs) has been altered with the impact of novel facts in molecular biology. The WHO2016 classification of RCCs includes the revisions as follows; 1) multilocular cystic RCC has been changed to multilocular cystic neoplasm with low malignant potential, 2)MiT translocation RCC has been introduced encompassing Xp11.2 and 6p21 translocation cases, 3) acquired cystic disease-associated RCC has been introduced as a hemodialysis-related type, 4) several other novel types have been introduced, i.e. clear cell papillary, tubulocystic, succinate dehydrogenase-deficient, hereditary leiomyomatosis RCC-associated, 5) renal medullary carcinoma and post-neuroblastoma RCC were deleted, and 6) novel nuclear grading system based on nucleolar size is recommended to apply to clear cell and papillary RCCs. In this review, we have presented general features of pathological diagnosis of RCCs and novel histological types.