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Ayako Nakamura-Ishizu
Department School of Medicine, School of Medicine Position Professor and Division head |
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| Article types | Review article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Hematopoietic Stem Cell Metabolism during Development and Aging. |
| Journal | Formal name：Developmental cell Abbreviation：Dev Cell ISSN code：18781551/15345807 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 54(2),pp.239-255 |
| Author and coauthor | Nakamura-Ishizu Ayako, Ito Keisuke, Suda Toshio |
| Publication date | 2020/07 |
| Summary | Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism. |
| DOI | 10.1016/j.devcel.2020.06.029 |
| PMID | 32693057 |