イシズ　アヤコ   Ayako Nakamura-Ishizu   石津　綾子    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	The analysis, roles and regulation of quiescence in hematopoietic stem cells.
掲載誌名	正式名：Development (Cambridge, England) 略　 称：Development ISSNコード：14779129/09501991
掲載区分	国外
巻・号・頁	141(24),pp.4656-66
著者・共著者	Nakamura-Ishizu Ayako, Takizawa Hitoshi, Suda Toshio
発行年月	2014/12
概要	Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of efficient self-renewal and differentiation; some of these have been shown to exist in a dormant, or quiescent, cell cycle state. Such quiescence has been proposed as a fundamental property of hematopoietic stem cells (HSCs) in the adult bone marrow, acting to protect HSCs from functional exhaustion and cellular insults to enable lifelong hematopoietic cell production. Recent studies have demonstrated that HSC quiescence is regulated by a complex network of cell-intrinsic and -extrinsic factors. In addition, detailed single-cell analyses and novel imaging techniques have identified functional heterogeneity within quiescent HSC populations and have begun to delineate the topological organization of quiescent HSCs. Here, we review the current methods available to measure quiescence in HSCs and discuss the roles of HSC quiescence and the various mechanisms by which HSC quiescence is maintained.
DOI	10.1242/dev.106575
PMID	25468935