Ayako Nakamura-Ishizu
   Department   School of Medicine, School of Medicine
   Position   Professor and Division head
Article types Review article
Language English
Peer review Peer reviewed
Title Hematopoietic stem cell niche: an interplay among a repertoire of multiple functional niches.
Journal Formal name:Biochimica et biophysica acta
Abbreviation:Biochim Biophys Acta
ISSN code:00063002/00063002
Domestic / ForeginForegin
Volume, Issue, Page 1830(2),pp.2404-9
Author and coauthor Nakamura-Ishizu Ayako, Suda Toshio
Publication date 2013/02
Summary BACKGROUND:Hematopoietic stem cell (HSC) niche of the BM provides a specialized microenvironment for the regulation of HSCs. The strict control of HSCs by the niche coordinates the balance between the proliferation and the differentiation of HSCs for the homeostasis of the blood system in steady states and during stress hematopoiesis. The osteoblastic and vascular niches are the classically identified constituents of the BM niche.SCOPE OF REVIEW:Recent research broadens our understanding of the BM niche as an assembly of multiple niche cells within the BM. We provide an overview of the HSC niche aiming to delineate the defined and possible niche cell interactions which collectively modulate the HSC integrity.MAJOR CONCLUSIONS:Multiple cells in the BM, including osteoblasts, vascular endothelia, perivascular mesenchymal cells and HSC progeny cells, function conjunctively as niche cells to regulate HSCs.GENERAL SIGNIFICANCE:The study of HSC niche cells and their functions provides insights into stem cell biology and also may be extrapolated into the study of cancer stem cells. This article is part of a Special Issue entitled Biochemistry of Stem Cells.
DOI 10.1016/j.bbagen.2012.08.023
PMID 22967757