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Ayako Nakamura-Ishizu
Department School of Medicine, School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Sphere formation restores and confers hair-inducing capacity in cultured mesenchymal cells. |
| Journal | Formal name：Experimental dermatology Abbreviation：Exp Dermatol ISSN code：16000625/09066705 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 20(8),pp.679-81 |
| Author and coauthor | Shimizu Ruka, Okabe Keisuke, Kubota Yoshiaki, Nakamura-Ishizu Ayako, Nakajima Hideo, Kishi Kazuo |
| Publication date | 2011/08 |
| Summary | Interactions between epithelial and dermal cells are essential for hair follicle morphogenesis and maintenance. In experimental trials of hair regeneration, isolated dermal cells have been shown to possess hair-inducing capacity. However, dermal cells lose this potential immediately after cultivation. Sphere-forming multipotent cells derived from the dermis possess hair-inducing capacity. These previous findings raise the question of whether hair-inducing capacity depends on the identity as dermal cells or the process of sphere formation. To address this issue, we compared the in vitro and in vivo characteristics of two-dimensionally cultured or thereafter sphere formation-induced dermal and lung mesenchymal cells. We show that sphere-forming mesenchymal cells exhibited higher expression of Wnt signalling genes. Sphere-forming cells but not two-dimensionally cultured cells possessed in vivo hair-inducing capacity. These data suggest that various mesenchymal cells attain hair-inducing capacity through the process of sphere formation. |
| DOI | 10.1111/j.1600-0625.2011.01281.x |
| PMID | 21521371 |