イシズ　アヤコ   Ayako Nakamura-Ishizu   石津　綾子    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	総説
言語種別	日本語
査読の有無	査読あり
表題	[Ageing of hematopoietic stem cells].
掲載誌名	正式名：[Rinsho ketsueki] The Japanese journal of clinical hematology 略　 称：Rinsho Ketsueki ISSNコード：04851439/04851439
掲載区分	国内
巻・号・頁	59(1),3-12頁
著者・共著者	Shiozaki Hiroko, Nakamura-Ishizu Ayako, Suda Toshio
発行年月	2018
概要	The frequency of clonal hematopoiesis in humans vastly increases with aging. Older adults may develop one or several clones and this condition is called clonal hematopoiesis of indeterminate potential (CHIP). Recent genetic analyses have identified the genes inducing CHIP. These mutant genes are detected frequently in elderly people and this condition is a precursor of hematopoietic neoplasms. The prevalence of hematopoietic neoplasms in patients with CHIP is tenfold that in those without CHIP. Consequently, the mechanism of aging and leukemogenesis of hematopoietic stem cells is being understood. Furthermore, the efficacy of senolysis, selectively removing scenescent cells from tissues, has been demonstrated in mice. The clinical application of senolysis is anticipated shortly.
DOI	10.11406/rinketsu.59.3
PMID	29415934