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Ayako Nakamura-Ishizu
Department School of Medicine, School of Medicine Position Professor and Division head |
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| Article types | Review article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation. |
| Journal | Formal name：Annals of the New York Academy of Sciences Abbreviation：Ann N Y Acad Sci ISSN code：17496632/00778923 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | pp.120 |
| Author and coauthor | Nakamura-Ishizu Ayako, Suda Toshio |
| Publication date | 2019/07 |
| Summary | Thrombopoietin (Thpo) and its receptor myeloid proliferative leukemia (Mpl) were initially identified as the cytokine signaling that stimulates megakaryopoiesis and platelet production. However, Thpo-Mpl signaling has also been widely characterized as one of the few cytokine systems that directly regulates hematopoietic stem and progenitor cells. The ability of Thpo signaling to stimulate hematopoietic stem cell (HSC) self-renewal has led to the development and utilization of Thpo mimetic drugs to treat hematopoietic diseases with restricted function of HSCs, such as aplastic anemia. This review will cover the mechanisms by which Thpo-Mpl signaling regulates HSCs. |
| DOI | 10.1111/nyas.14169 |
| PMID | 31292976 |