イシズ　アヤコ   Ayako Nakamura-Ishizu   石津　綾子    所属   医学部 医学科    職種   教授・基幹分野長
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Multifaceted roles of thrombopoietin in hematopoietic stem cell regulation.
掲載誌名	正式名：Annals of the New York Academy of Sciences 略　 称：Ann N Y Acad Sci ISSNコード：17496632/00778923
掲載区分	国外
巻・号・頁	pp.120
著者・共著者	Nakamura-Ishizu Ayako, Suda Toshio
発行年月	2019/07
概要	Thrombopoietin (Thpo) and its receptor myeloid proliferative leukemia (Mpl) were initially identified as the cytokine signaling that stimulates megakaryopoiesis and platelet production. However, Thpo-Mpl signaling has also been widely characterized as one of the few cytokine systems that directly regulates hematopoietic stem and progenitor cells. The ability of Thpo signaling to stimulate hematopoietic stem cell (HSC) self-renewal has led to the development and utilization of Thpo mimetic drugs to treat hematopoietic diseases with restricted function of HSCs, such as aplastic anemia. This review will cover the mechanisms by which Thpo-Mpl signaling regulates HSCs.
DOI	10.1111/nyas.14169
PMID	31292976