シノハラ　アキヒト   篠原　明仁    所属   医学部 医学科（東京女子医科大学病院）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Very Early Increased Platelet Count within a Week after Initiation of High-Dose Dexamethasone Treatment Is Associated with Long-Term Response in Newly Diagnosed Immune Thrombocytopenia Patients.
掲載誌名	正式名：Acta haematologica 略　 称：Acta Haematol ISSNコード：14219662/00015792
掲載区分	国外
巻・号・頁	145(2),pp.193-200
著者・共著者	Ishiyama Midori†, Shiseki Masayuki, Yoshinaga Kentaro, Ryuzaki Michiko, Izuka Yuki, Watanabe Aya, Tanaka Norina, Shinohara Akihito, Hagiwara Shotaro, Tanaka Junji
発行年月	2022/02
概要	To evaluate the long-term efficacy of high-dose dexamethasone (HD-DXM) treatment for immune thrombocytopenia (ITP), we retrospectively analysed 36 newly diagnosed ITP patients treated with HD-DXM as a first-line treatment. An initial response was obtained in 23 (63.9%) patients, including 11 with a complete response (CR) and 12 with a partial response (PR). Six months after HD-DXM treatment, 26 of 33 (78.8%) evaluable patients achieved objective responses, including 18 CR and 8 PR. Among 13 patients without initial response, very early increased platelet count within a week (VEIP) was observed in 7 patients, 5 (71.4%) of whom achieved a response at 6 months. In 29 patients who had available platelet count within a week, patients showing VEIP revealed longer survival than those who did not (p = 0.026). HD-DXM was an effective treatment for newly diagnosed ITP patients. VEIP after HD-DXM treatment initiation was associated with a long-term objective response in newly diagnosed ITP patients.
DOI	10.1159/000518744
PMID	34818223