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Wakabayashi Hidetaka
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Use of antipsychotics is negatively associated with muscle strength in older adults with sarcopenia after stroke. |
| Journal | Formal name：Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Abbreviation：J Stroke Cerebrovasc Dis ISSN code：15328511/10523057 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 31(8),pp.106587 |
| Author and coauthor | Kose Eiji, Yoshimura Yoshihiro, Wakabayashi Hidetaka, Matsumoto Ayaka |
| Publication date | 2022/07 |
| Summary | OBJECTIVE:The use of antipsychotics has been shown to affect activities of daily living during rehabilitation but reports regarding their effects on older patients with sarcopenia are insufficient. We aimed to examine the effect of the use of antipsychotics on muscle strength and muscle mass in older patients with sarcopenia undergoing convalescent rehabilitation after stroke.METHODS:This retrospective cohort study was conducted at a rehabilitation hospital between 2015 and 2020. The study outcomes included skeletal muscle mass index and hand grip strength at discharge. Multivariate analyses were used to determine whether the use of antipsychotics at admission and at 4 weeks after admission were independently associated with the study outcomes, after adjusting for potential confounders.RESULTS:Of the 619 stroke patients admitted, 196 (mean age 81 years; 44.4% men) had sarcopenia at admission and were included in the final analysis. The median hand grip strength and median skeletal muscle mass index values were 12.5 (5.9-17.9) kg and 5.1 (4.5-6.0) kg/m2, respectively. In the multivariate analyses, the use of antipsychotics at 4 weeks post-admission was independently associated with hand grip strength at discharge (β = -0.125, p = 0.008), which was not the case when used at admission. Furthermore, the use of antipsychotics at admission and at 4 weeks after admission were not significantly associated with the skeletal muscle mass index at discharge.CONCLUSIONS:The use of antipsychotics in older patients with sarcopenia after stroke was negatively associated with handgrip strength at discharge. |
| DOI | 10.1016/j.jstrokecerebrovasdis.2022.106587 |
| PMID | 35793581 |