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Wakabayashi Hidetaka
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Deprescribing Leads to Improved Energy Intake among Hospitalized Older Sarcopenic Adults with Polypharmacy after Stroke. |
| Journal | Formal name：Nutrients Abbreviation：Nutrients ISSN code：20726643/20726643 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 14(3),pp.1 |
| Author and coauthor | Matsumoto Ayaka, Yoshimura Yoshihiro, Wakabayashi Hidetaka, Kose Eiji, Nagano Fumihiko, Bise Takahiro, Kido Yoshifumi, Shimazu Sayuri, Shiraishi Ai |
| Publication date | 2022/01 |
| Summary | Evidence is scarce regarding the polypharmacy in patients with sarcopenia. The aim of this study was to investigate the effect of deprescribing for polypharmacy on the improvement of nutritional intake and sarcopenia in older patients with sarcopenia. A retrospective cohort study was conducted with hospitalized older patients with sarcopenia undergoing rehabilitation after stroke. Study outcomes included energy intake, protein intake, handgrip strength (HG) and skeletal muscle mass index (SMI) at hospital discharge. To consider the effects of deprescribing for polypharmacy, we used multivariate analyses to examine whether the change in the number of medications during hospitalization was associated with outcomes. Of 361 patients after enrollment, 91 (mean age 81.0 years, 48.4% male) presented with sarcopenia and polypharmacy and were eligible for analysis. The change in the number of medications was independently associated with energy intake (β = -0.237, p = 0.009) and protein intake (β = -0.242, p = 0.047) at discharge, and was not statistically significantly associated with HG (β = -0.018, p = 0.768) and SMI (β = 0.083, p = 0.265) at discharge, respectively. Deprescribing was associated with improved nutritional intake in older sarcopenic patients with polypharmacy undergoing stroke rehabilitation. |
| DOI | 10.3390/nu14030443 |
| PMID | 35276802 |