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種田 積子
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Slowly Progressive Male Alport Syndrome Evaluated by Serial Biopsy: Importance of Type IV Collagen Staining. |
| Journal | Formal name：Internal medicine (Tokyo, Japan) Abbreviation：Intern Med ISSN code：13497235/09182918 |
| Volume, Issue, Page | 61(8),pp.1205-1209 |
| Author and coauthor | Sato Masayo, Manabe Shun, Itabashi Mitsuyo, Horita Shigeru, Hirose Orie, Kawashima Moe, Nishida Miki, Kataoka Hiroshi, Taneda Sekiko, Mochizuki Toshio, Nitta Kosaku |
| Publication date | 2022/04 |
| Summary | A slowly progressive middle-aged man initially diagnosed with thin basement membrane nephropathy based on extensive thinning of the glomerular basement membrane (GBM) was subsequently diagnosed with Alport syndrome (AS) by a serial renal biopsy eight years later. The ultrastructural analysis of the second biopsy indicated thickening and wrinkling with mild reticulation in the GBM, consistent with AS. However, a retrospective analysis of the first biopsy revealed mild attenuation of type IV collagen α5 chain staining, suggesting a potential diagnosis of AS, despite the lack of ultrastructural features of AS. We herein report the clinical usefulness of type IV collagen staining in the early diagnosis of AS. |
| DOI | 10.2169/internalmedicine.7372-21 |
| PMID | 34645753 |