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大野 秀樹
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Assistant Professor |
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| Article types | Case report |
| Language | Japanese |
| Peer review | Peer reviewed |
| Title | Efficacy and parameter-kinetics of mac-2 binding protein glycosylation isomer (M2BPGi) and magnetic resonance elastography in hepatitis C patients with direct acting antiviral therapy: Case series of 5 hemodialysis patients |
| Journal | Formal name：Journal of Japanese Society of Dialysis Therapy ISSN code：1340-3451 |
| Domestic / Foregin | Domestic |
| Publisher | The Japanese Society of Dialysis Therapy |
| Volume, Issue, Page | pp.645-652 |
| Author and coauthor | Yoko Nishizawa†*, Hideki Ohno, Ayako Kimura, Eriko Hirasawa, Mai Tosaka, Yumi Hosoda, Erika Yamaguchi, Ai Horimoto, Kiyotsugu Omae, Ken Tsuchiya, Kosaku Nitta, Hiroshi Sakura, Tetsuya Ogawa |
| Authorship | 2nd author |
| Publication date | 2022/11 |
| Summary | Liver fibrosis (LF) progresses more slowly after the elimination of the hepatitis C virus (HCV) by antiviral therapy.
Liver biopsy is the gold standard for evaluating LF； however, it is invasive and can cause procedure‒related complications. Therefore, non‒invasive LF parameters are desired. Magnetic resonance elastography (MRE) is as accurate at assessing LF as liver biopsy. Mac‒2 binding protein glycosylation isomer (M2BPGi) was reported to be a reliable serum marker for predicting LF and measuring liver function after antiviral therapy. HCV infections are relatively common among dialysis patients； however, the kinetics of the abovementioned non‒invasive LF parameters in dialysis patients are unknown. Herein, we described the cases of 5 HCV‒infected dialysis patients that were treated with direct‒acting antivirals and underwent liver MRE and M2BPGi monitoring before and after treatment. All patients achieved sustained virological responses at 12 and 24 weeks. The mean liver MRE values of the LC (n＝1) and non‒LC (n＝2) patients were 5.6, and 2.25 and 2.9 kPa, respectively, and did not change after treatment. On the other hand, the M2BPGi levels of the LC and non‒LC groups decreased from 2.59 to 1.51 C.O.I. and from 1.88 to 1.31 C.O.I., respectively, after treatment. Liver MRE was effective and accurate at assessing liver fibrosis in dialysis patients. Also, the M2BPGi levels of dialysis patients decreased after direct‒acting antiviral treatment, as has been reported for non‒dialysis patients. |
| DOI | https://doi.org/10.4009/jsdt.55.645 |