オオノ　ヒデキ   大野　秀樹    所属   医学部 医学科（附属足立医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors
掲載誌名	正式名：Biochem Biophys Res Commun ISSNコード：1090-2104 (Electronic) 0006-291X (Linking
掲載区分	国外
巻・号・頁	432,pp.586-592
著者・共著者	Mashima, H Ohno, H Yamada, Y Sakai, T Ohnishi, H
担当区分	2nd著者
発行年月	2013
概要	Insulin-like peptide 5 (INSL5) is a member of the insulin superfamily, and is a potent agonist for RXFP4. We have shown that INSL5 is expressed in enteroendocrine cells (EECs) along the colorectum with a gradient increase toward the rectum. RXFP4 is ubiquitously expressed along the digestive tract. INSL5-positive EECs have little immunoreactivity to chromogranin A (CgA) and might be a unique marker of colorectal EECs. CgA-positive EECs were distributed normally along the colorectum in INSL5 null mice, suggesting that INSL5 is not required for the development of CgA-positive EECs. Exogenous INSL5 did not affect the proliferation of human colon cancer cell lines, and chemically-induced colitis in INSL5 null mice did not show any significant changes in inflammation or mucosal healing compared to wild-type mice. In contrast, all of the rectal neuroendocrine tumors examined co-expressed INSL5 and RXFP4. INSL5 may be a unique marker of colorectal EECs, and INSL5-RXFP4 signaling might play a role in an autocrine/paracrine fashion in the colorectal epithelium and rectal neuroendocrine tumors.
DOI	10.1016/j.bbrc.2013.02.042
文献番号	23438439