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猪狩 勝則
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Endowed Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis. |
| Journal | Formal name：The FEBS journal Abbreviation：FEBS J ISSN code：(1742-464X)1742-464X(Linking) |
| Volume, Issue, Page | 274(18),pp.4904-4912 |
| Author and coauthor | IWAMOTO Takuji, OKAMOTO Hiroshi, KOBAYASHI Shu, IKARI Katsunori, TOYAMA Yoshiaki, KAMATANI NAOYUKI, MOMOHARA Shigeki |
| Publication date | 2007/09 |
| Summary | We studied the role of monocyte chemoattractant (MCP)-4/CCL13 in the pathogenesis of rheumatoid arthritis (RA). MCP-4 was highly expressed in cartilage from RA patients. Interferon-gamma significantly stimulated MCP-4/CCL13 production in human chondrocytes, and this effect was enhanced in combination with interleukin-1beta or tumor necrosis factor-alpha. MCP-4/CCL13 induces the phosphorylation of extracellular signal-regulated kinase in fibroblast-like synoviocytes and activates cell proliferation, and PD98059 completely inhibits these effects. These data suggest that interferon-gamma in combination with interleukin-1beta/tumor necrosis factor-alpha activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade. |
| DOI | 10.1111/j.1742-4658.2007.06013.x |
| PMID | 17824960 |