イカリ　カツノリ   猪狩　勝則    所属   医学部 医学科（東京女子医科大学病院）    職種   寄附部門教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	A role of monocyte chemoattractant protein-4 (MCP-4)/CCL13 from chondrocytes in rheumatoid arthritis.
掲載誌名	正式名：The FEBS journal 略　 称：FEBS J ISSNコード：(1742-464X)1742-464X(Linking)
巻・号・頁	274(18),pp.4904-4912
著者・共著者	IWAMOTO Takuji, OKAMOTO Hiroshi, KOBAYASHI Shu, IKARI Katsunori, TOYAMA Yoshiaki, KAMATANI NAOYUKI, MOMOHARA Shigeki
発行年月	2007/09
概要	We studied the role of monocyte chemoattractant (MCP)-4/CCL13 in the pathogenesis of rheumatoid arthritis (RA). MCP-4 was highly expressed in cartilage from RA patients. Interferon-gamma significantly stimulated MCP-4/CCL13 production in human chondrocytes, and this effect was enhanced in combination with interleukin-1beta or tumor necrosis factor-alpha. MCP-4/CCL13 induces the phosphorylation of extracellular signal-regulated kinase in fibroblast-like synoviocytes and activates cell proliferation, and PD98059 completely inhibits these effects. These data suggest that interferon-gamma in combination with interleukin-1beta/tumor necrosis factor-alpha activates the production of MCP-4/CCL13 from chondrocytes in RA joints, and that secreted MCP-4/CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated kinase mitogen-activated protein kinase cascade.
DOI	10.1111/j.1742-4658.2007.06013.x
PMID	17824960