中林　章    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Associate Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Current status of preimplantation genetic diagnosis in Japan.
Journal	Formal name：Bioinformation Abbreviation：Bioinformation ISSN code：09732063/09732063
Domestic / Foregin	Foregin
Volume, Issue, Page	11(5),pp.254-60
Author and coauthor	Sato Kenji, Sueoka Kou, Iino Kotaro, Senba Hiroshi, Suzuki Mariko, Mizuguchi Yuki, Izumi Yoko, Sato Suguru, Nakabayashi Akira, Tanaka Mamoru
Publication date	2015
Summary	This is a retrospective study aimingto clarify the current status of preimplantation genetic diagnosis (PGD) in Japan. Our data were collected from 12 facilities between September 2004 and September 2012, and entered into a database. A majority of PGD in Japan was performed for balanced structural chromosomal abnormalities in couples with recurrent miscarriage. PGD for monogenic diseases was performed only in two facilities. The average maternal age was 38 years for monogenic diseases and 40 years for chromosomal abnormalities. Overall there have been671 cycles to oocyte retrieval reported. Of these cycles, 85% (572 cycles)were for chromosomal abnormalities, and 15% (99 cycles) for monogenic diseases. Diagnosis rates in the current study were 70.8% for monogenic diseases and 94.0% for chromosomal abnormalities. Rates of embryo transfer of PGD were 62.7% for monogenic diseases and 25.5% for chromosomal abnormalities. Clinical pregnancy rates per embryo transfer were 12.0% for monogenic diseases and 35.6% for chromosomal abnormalities. Our study is the first PGD report from all facilities which had the approval of the ethics committee of the Japanese Society of Obstetrics and Gynecology. We have built a basis for gathering continuous PGD data in Japan.
DOI	10.6026/97320630011254
PMID	26124570