ナカバヤシ　アキラ   中林　章    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Green tea extracts attenuate doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity in mice.
掲載誌名	正式名：Journal of assisted reproduction and genetics 略　 称：J Assist Reprod Genet ISSNコード：15737330/10580468
掲載区分	国外
巻・号・頁	27(8),pp.501-8
著者・共著者	Sato Kenji, Sueoka Kou, Tanigaki Reiko, Tajima Hiroto, Nakabayashi Akira, Yoshimura Yasunori, Hosoi Yoshihiko
発行年月	2010/08
概要	PURPOSE:The aim of this study was to investigate the protective effect of green tea extracts against doxorubicin-induced damage in the mouse testes correlating with telomerase activity.METHODS:Green tea extracts were administered orally. Doxorubicin was coadministered intraperitoneally. These testes were evaluated histologically and the telomerase activity was analyzed. Additional immunostaining was carried out.RESULTS:Both the sperm density and sperm motility were significantly increased in green tea extracts coadministration groups as compared to the doxorubicin-treated groups. By histological analysis, germ cell damage was greatly attenuated by green tea extracts coadministration. Telomerase activity significantly increased in association with the coadministration of green tea extracts as compared to that of doxorubicin-only groups. In all groups, human telomerase reverse transcriptase signals were mainly observed in the spermatocytes and spermatids.CONCLUSIONS:These findings suggest that green tea extracts exert protective effects against doxorubicin-induced spermatogenic disorders in conjunction with higher telomerase activity levels.
DOI	10.1007/s10815-010-9438-z
PMID	20505988