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OSHIBUCHI Hidehiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. |
| Journal | Formal name：Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Abbreviation：Neuropsychopharmacology ISSN code：(1740-634X)0893-133X(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 41(5),pp.1404-15 |
| Author and coauthor | Urban Daniel J, Zhu Hu, Marcinkiewcz Catherine A, Michaelides Michael, Oshibuchi Hidehiro, Rhea Darren, Aryal Dipendra K, Farrell Martilias S, Lowery-Gionta Emily, Olsen Reid H J, Wetsel William C, Kash Thomas L, Hurd Yasmin L, Tecott Laurence H, Roth Bryan L |
| Publication date | 2016/04 |
| Summary | Elucidating how the brain's serotonergic network mediates diverse behavioral actions over both relatively short (minutes-hours) and long period of time (days-weeks) remains a major challenge for neuroscience. Our relative ignorance is largely due to the lack of technologies with robustness, reversibility, and spatio-temporal control. Recently, we have demonstrated that our chemogenetic approach (eg, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)) provides a reliable and robust tool for controlling genetically defined neural populations. Here we show how short- and long-term activation of dorsal raphe nucleus (DRN) serotonergic neurons induces robust behavioral responses. We found that both short- and long-term activation of DRN serotonergic neurons induce antidepressant-like behavioral responses. However, only short-term activation induces anxiogenic-like behaviors. In parallel, these behavioral phenotypes were associated with a metabolic map of whole brain network activity via a recently developed non-invasive imaging technology DREAMM (DREADD Associated Metabolic Mapping). Our findings reveal a previously unappreciated brain network elicited by selective activation of DRN serotonin neurons and illuminate potential therapeutic and adverse effects of drugs targeting DRN neurons. |
| DOI | 10.1038/npp.2015.293 |
| PMID | 26383016 |