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フルイチ ヨシヒロ
古市 好宏 所属 医学部 医学科（附属足立医療センター） 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | The Risk of Cirrhosis and Its Complications Based on PNPLA3 rs738409 G Allele Frequency. |
| 掲載誌名 | 正式名：Digestive diseases (Basel, Switzerland) 略 称：Dig Dis ISSNコード：14219875/02572753 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 40(5),pp.625-634 |
| 著者・共著者 | Shao Xue, Uojima Haruki, Arai Taeang, Ogawa Yuji, Setsu Toru, Atsukawa Masanori, Furuichi Yoshihiro, Arase Yoshitaka, Horio Kazue, Hidaka Hisashi, Nakazawa Takahide, Kako Makoto, Kagawa Tatehiro, Iwakiri Katsuhiko, Nakajima Atsushi, Terai Shuji, Tanaka Yasuhito, Koizumi Wasaburo |
| 発行年月 | 2022 |
| 概要 | BACKGROUND:Data regarding the influence of patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism for patients with liver cirrhosis (LC) are scarce.OBJECTIVE:This study assesses the role of the PNPLA3 polymorphism for the development of LC and its complications by the findings of genetic examinations.METHODS:Patients with LC caused by virus (n = 157), alcohol (n = 104), nonalcoholic fatty liver disease (NAFLD) (n = 106), or autoimmune disease (n = 33) and without LC (n = 128) were enrolled. LC was composed of the presence and absence of complications, such as variceal bleeding, hepatic ascites, and hepatic encephalopathy. To assess the role of the PNPLA3 polymorphism, odds ratio (OR) for the rs738409 variant was calculated for the patients between (i) with LC and without LC in the entire cohort and (ii) the presence and absence of complications in the patients with LC.RESULTS:There was a significant difference among the patients without LC and those with alcohol, NAFLD-related LC in the frequency of G alleles (p < 0.001, both). According to complications of LC, the OR for NAFLD-related cirrhosis significantly increased in the presence of the two mutated alleles (OR = 3.165; p = 0.046) when the wild type was used as the reference. However, there were no significant risks for the complications in the virus and alcohol-related cirrhosis unless there was a presence of G alleles.CONCLUSION:The PNPLA3 polymorphism was associated with the risk of NAFLD-related LC and its complications. |
| DOI | 10.1159/000521062 |
| PMID | 34808618 |