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フルイチ ヨシヒロ
古市 好宏 所属 医学部 医学科（附属足立医療センター） 職種 准教授 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Usefulness of autotaxin for the complications of liver cirrhosis. |
| 掲載誌名 | 正式名：World journal of gastroenterology 略 称：World J Gastroenterol ISSNコード：22192840/10079327 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 26(1),pp.97-108 |
| 著者・共著者 | Shao Xue, Uojima Haruki, Setsu Toru, Okubo Tomomi, Atsukawa Masanori, Furuichi Yoshihiro, Arase Yoshitaka, Hidaka Hisashi, Tanaka Yoshiaki, Nakazawa Takahide, Kako Makoto, Kagawa Tatehiro, Iwakiri Katsuhiko, Terai Shuji, Koizumi Wasaburo |
| 発行年月 | 2020/01 |
| 概要 | BACKGROUND:Autotaxin (ATX) has been reported as a direct biomarker for estimating the evaluation of liver fibrosis. But available data on ATX as a useful biomarker for the complications of liver cirrhosis (LC) are scant.AIM:To assess the clinical usefulness of ATX for assessing the complications of LC.METHODS:This multicenter, retrospective study was conducted at six locations in Japan. We include patients with LC, n = 400. The ATX level was evaluated separately in men and women because of its high level in female patients. To assess the clinical usefulness of ATX for the complications of LC, the area under the curve (AUC) of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score, albumin-bilirubin (ALBI) score, fibrosis-4 index, and aspartate aminotransferase-to-platelet ratio index.RESULTS:The mean age was 68.4 ± 11.4 years, 240 patients (60.0%) were male. A total of 213 (53.3%) and 187 (46.8%) patients were compensated and decompensated, respectively. The numbers of patients with varix rupture, hepatic ascites, and hepatic encephalopathy were 35 (8.8%), 131 (32.8%), and 103 (25.8%), respectively. The AUCs of ATX in men for hepatic encephalopathy, hepatic ascites, and varix ruptures were 0.853, 0.816, and 0.706, respectively. The AUCs of ATX in women for hepatic encephalopathy, hepatic ascites, and varix rupture were 0.759, 0.717, and 0.697, respectively. The AUCs of ATX in men were higher than those in women, as were all the other biomarkers used to detect encephalopathy and varix ruptures. However, for detecting ascites, the AUC of ALBI in men was more effective than using ATX.CONCLUSION:ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures. |
| DOI | 10.3748/wjg.v26.i1.97 |
| PMID | 31933517 |