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古市 好宏
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Viscoelasticity Measurement in Rat Livers Using Shear-Wave US Elastography. |
| Journal | Formal name：Ultrasound in medicine & biology Abbreviation：Ultrasound Med Biol ISSN code：1879291X/03015629 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 44(9),pp.2018-2024 |
| Author and coauthor | Sugimoto Katsutoshi, Moriyasu Fuminori, Oshiro Hisashi, Takeuchi Hirohito, Yoshimasu Yu, Kasai Yoshitaka, Furuichi Yoshihiro, Itoi Takao |
| Publication date | 2018/09 |
| Summary | To investigate the usefulness of shear-wave speed and dispersion slope measurements obtained, using an ultrasound elastography system in rat livers with various degrees of necroinflammation and fibrosis. A total of 25 male Sprague Dawley rats were randomly divided into 5 groups of 5 rats each: G0 (control), G1 (CCl4 injected twice a week for 1 wk), G2 (CCl4 injected four times a wk for 1 wk), G3 (CCl4 injected twice a wk for 6 wk) and G4 (CCl4 injected twice a wk for 10 wk). The shear-wave speed (m/s) and the dispersion slope ([m/s]/kHz) were measured. Histologic features (inflammation, necrosis and fibrosis) were used as reference standards. In multivariable analysis with histologic features as independent variables, the fibrosis grade was significantly related to shear-wave speed (p < 0.05) and the necrosis grade was significantly related to dispersion slope (p < 0.05). Dispersion slope is more useful than shear-wave speed for predicting the degree of necroinflammation. |
| DOI | 10.1016/j.ultrasmedbio.2018.05.008 |
| PMID | 29936025 |