古市　好宏
   Department   School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study.
Journal Formal name：SpringerPlus
Abbreviation：Springerplus
ISSN code：21931801/21931801
Domestic / ForeginForegin
Volume, Issue, Page 5(1),pp.749
Author and coauthor Sugimoto Katsutoshi, Moriyasu Fuminori, Takeuchi Hirohito, Kojima Mayumi, Ogawa Saori, Sano Takatomo, Furuichi Yoshihiro, Kobayashi Yoshiyuki, Nakamura Ikuo
Publication date 2016
Summary OBJECTIVE:To determine the optimal bolus injection rate of ultrasound (US) contrast agent in vascular imaging for focal liver lesions.METHODS:Thirteen patients with 13 focal liver lesions (5 hepatocellular carcinomas (HCCs) with cirrhosis, 4 liver metastases, 2 hemangiomas, 1 intrahepatic cholangiocarcinoma, 1 focal nodular hyperplasia) received two bolus injections of Sonazoid (at 0.5 and 2.0 mL/s) using an automatic power injector. The lesion-to-liver contrast ratio at peak enhancement was quantitatively evaluated. Enhancement of the lesions compared to liver parenchyma was assessed by two independent readers using a five-point scale and qualitatively evaluated by receiver operating characteristic (ROC) analysis.RESULTS:For all lesions, the contrast ratio was not significantly different between the two injection rates. For HCCs, the contrast ratio was higher at 0.5 mL/s (7.41 ± 6.56) than at 2.0 mL/s (4.28 ± 4.66, p = 0.025). For all lesions, the mean area under the ROC curve (AUC) was not significantly different between the two injection rates. For HCCs, the AUC was greater at 0.5 mL/s than at 2.0 mL/s (AUC: 0.86, p = 0.013).CONCLUSION:In contrast-enhanced US, an injection rate of 0.5 mL/s is superior to an injection rate of 2.0 mL/s for the quantitative and qualitative analysis of HCCs in the cirrhotic liver.
DOI 10.1186/s40064-016-2364-5
PMID 27386232