フルイチ　ヨシヒロ   古市　好宏    所属   医学部 医学科（附属足立医療センター）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Optimal injection rate of ultrasound contrast agent for evaluation of focal liver lesions using an automatic power injector: a pilot study.
掲載誌名	正式名：SpringerPlus 略　 称：Springerplus ISSNコード：21931801/21931801
掲載区分	国外
巻・号・頁	5(1),pp.749
著者・共著者	Sugimoto Katsutoshi, Moriyasu Fuminori, Takeuchi Hirohito, Kojima Mayumi, Ogawa Saori, Sano Takatomo, Furuichi Yoshihiro, Kobayashi Yoshiyuki, Nakamura Ikuo
発行年月	2016
概要	OBJECTIVE:To determine the optimal bolus injection rate of ultrasound (US) contrast agent in vascular imaging for focal liver lesions.METHODS:Thirteen patients with 13 focal liver lesions (5 hepatocellular carcinomas (HCCs) with cirrhosis, 4 liver metastases, 2 hemangiomas, 1 intrahepatic cholangiocarcinoma, 1 focal nodular hyperplasia) received two bolus injections of Sonazoid (at 0.5 and 2.0 mL/s) using an automatic power injector. The lesion-to-liver contrast ratio at peak enhancement was quantitatively evaluated. Enhancement of the lesions compared to liver parenchyma was assessed by two independent readers using a five-point scale and qualitatively evaluated by receiver operating characteristic (ROC) analysis.RESULTS:For all lesions, the contrast ratio was not significantly different between the two injection rates. For HCCs, the contrast ratio was higher at 0.5 mL/s (7.41 ± 6.56) than at 2.0 mL/s (4.28 ± 4.66, p = 0.025). For all lesions, the mean area under the ROC curve (AUC) was not significantly different between the two injection rates. For HCCs, the AUC was greater at 0.5 mL/s than at 2.0 mL/s (AUC: 0.86, p = 0.013).CONCLUSION:In contrast-enhanced US, an injection rate of 0.5 mL/s is superior to an injection rate of 2.0 mL/s for the quantitative and qualitative analysis of HCCs in the cirrhotic liver.
DOI	10.1186/s40064-016-2364-5
PMID	27386232