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古市 好宏
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Irreversible electroporation for nonthermal tumor ablation in patients with hepatocellular carcinoma: initial clinical experience in Japan. |
| Journal | Formal name：Japanese journal of radiology Abbreviation：Jpn J Radiol ISSN code：1867108X/18671071 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 33(7),pp.424-32 |
| Author and coauthor | Sugimoto Katsutoshi, Moriyasu Fuminori, Kobayashi Yoshiyuki, Saito Kazuhiro, Takeuchi Hirohito, Ogawa Saori, Ando Mayumi, Sano Takatomo, Mori Toshifumi, Furuichi Yoshihiro, Nakamura Ikuo |
| Publication date | 2015/07 |
| Summary | PURPOSE:This clinical study was conducted to evaluate the safety and short-term outcomes of irreversible electroporation (IRE) for the treatment of patients with hepatocellular carcinoma (HCC) in Japan.MATERIALS AND METHODS:The study was designed in a prospective setting. Five patients (3 men and 2 women; mean age, 66.6 ± 5.8 years) with 6 HCCs were enrolled and treated using percutaneous ultrasound (US)-guided IRE. Safety was assessed based on adverse events and laboratory values. Local control was assessed using contrast-enhanced US with a perflubutane microbubble contrast agent, contrast-enhanced multiphase CT, and gadoxetic acid-enhanced MRI (EOB-MRI) at designated points.RESULTS:The tumors ranged in diameter from 11 to 28 mm (mean diameter, 17.5 ± 6.3 mm). Five of the 6 tumors (83 %) were successfully treated, with no local recurrence to date (mean follow-up 244 ± 55 days). In 1 lesion located in liver segment 1, residual tumor was diagnosed at 7 days after intervention by follow-up EOB-MRI. No serious complications related to the IRE procedure were observed.CONCLUSION:The results of this study suggest that image-guided percutaneous IRE can achieve satisfactory local disease control, particularly for small HCCs, and is well tolerated by patients. |
| DOI | 10.1007/s11604-015-0442-1 |
| PMID | 26032929 |