フルイチ　ヨシヒロ   古市　好宏    所属   医学部 医学科（附属足立医療センター）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Oscillating CD8(+) T cell effector functions after antigen recognition in the liver.
掲載誌名	正式名：Immunity 略　 称：Immunity ISSNコード：10747613/10747613
掲載区分	国外
巻・号・頁	23(1),pp.53-63
著者・共著者	Isogawa Masanori, Furuichi Yoshihiro, Chisari Francis V
発行年月	2005/07
概要	When hepatitis B virus (HBV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) are adoptively transferred into HBV transgenic mice, they enter the liver, recognize antigen, secrete interferon gamma (IFNgamma), inhibit viral replication, and kill their target cells, causing hepatitis. In the current study, we examined the impact of antigen recognition on the evolution of the activation phenotype, antiviral effector functions, expansion and contraction kinetics, and compartmentalization of the transferred CTLs. The results reveal that noncytolytic and cytolytic effector functions and expansion-contraction kinetics of the CTLs are regulated asynchronously and in an oscillatory manner as a consequence of antigen recognition in the liver and in association with PD-1 upregulation. We suggest that such oscillations maximize viral clearance and minimize tissue injury during HBV infection and that poor coordination of these events could lead to viral persistence and chronic liver disease.
DOI	10.1016/j.immuni.2005.05.005
PMID	16039579