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古市 好宏
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. |
| Journal | Formal name：Journal of virology Abbreviation：J Virol ISSN code：0022538X/0022538X |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 79(11),pp.7269-72 |
| Author and coauthor | Isogawa Masanori, Robek Michael D, Furuichi Yoshihiro, Chisari Francis V |
| Publication date | 2005/06 |
| Summary | Toll-like receptors (TLR) play a key role in innate immunity. To examine the ability of diverse TLRs to modulate hepatitis B virus (HBV) replication, HBV transgenic mice received a single intravenous injection of ligands specific for TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9. All of the ligands except for TLR2 inhibited HBV replication in the liver noncytopathically within 24 h in a alpha/beta interferon-dependent manner. The ability of these TLR ligands to induce antiviral cytokines at the site of HBV replication suggests that TLR activation could represent a powerful and novel therapeutic strategy for the treatment of chronic HBV infection. |
| DOI | 10.1128/JVI.79.11.7269-7272.2005 |
| PMID | 15890966 |