フルイチ　ヨシヒロ   古市　好宏    所属   医学部 医学科（附属足立医療センター）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.
掲載誌名	正式名：Journal of virology 略　 称：J Virol ISSNコード：0022538X/0022538X
掲載区分	国外
巻・号・頁	79(11),pp.7269-72
著者・共著者	Isogawa Masanori, Robek Michael D, Furuichi Yoshihiro, Chisari Francis V
発行年月	2005/06
概要	Toll-like receptors (TLR) play a key role in innate immunity. To examine the ability of diverse TLRs to modulate hepatitis B virus (HBV) replication, HBV transgenic mice received a single intravenous injection of ligands specific for TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9. All of the ligands except for TLR2 inhibited HBV replication in the liver noncytopathically within 24 h in a alpha/beta interferon-dependent manner. The ability of these TLR ligands to induce antiviral cytokines at the site of HBV replication suggests that TLR activation could represent a powerful and novel therapeutic strategy for the treatment of chronic HBV infection.
DOI	10.1128/JVI.79.11.7269-7272.2005
PMID	15890966