コガ ヨウコ
Yoko Kawase-Koga
古賀 陽子 所属 医学部 医学科(東京女子医科大学病院) 職種 教授・基幹分野長 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Protein expression profiles characterize distinct features of mouse cerebral cortices at different developmental stages. |
掲載誌名 | 正式名:PloS one 略 称:PLoS One ISSNコード:19326203/19326203 |
掲載区分 | 国外 |
巻・号・頁 | 10(4),pp.e0125608 |
著者・共著者 | Zhang Haijun, Kawase-Koga Yoko, Sun Tao |
発行年月 | 2015 |
概要 | The proper development of the mammalian cerebral cortex requires precise protein synthesis and accurate regulation of protein expression levels. To reveal signatures of protein expression in developing mouse cortices, we here generate proteomic profiles of cortices at embryonic and postnatal stages using tandem mass spectrometry (MS/MS). We found that protein expression profiles are mostly consistent with biological features of the developing cortex. Gene Ontology (GO) and KEGG pathway analyses demonstrate conserved molecules that maintain cortical development such as proteins involved in metabolism. GO and KEGG pathway analyses further identify differentially expressed proteins that function at specific stages, for example proteins regulating the cell cycle in the embryonic cortex, and proteins controlling axon guidance in the postnatal cortex, suggesting that distinct protein expression profiles determine biological events in the developing cortex. Furthermore, the STRING network analysis has revealed that many proteins control a single biological event, such as the cell cycle regulation, through cohesive interactions, indicating a complex network regulation in the cortex. Our study has identified protein networks that control the cortical development and has provided a protein reference for further investigation of protein interactions in the cortex. |
DOI | 10.1371/journal.pone.0125608 |
PMID | 25915664 |