コガ　ヨウコ   Yoko Kawase-Koga   古賀　陽子    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	MicroRNA function is required for neurite outgrowth of mature neurons in the mouse postnatal cerebral cortex.
掲載誌名	正式名：Frontiers in cellular neuroscience 略　 称：Front Cell Neurosci ISSNコード：16625102/16625102
掲載区分	国外
巻・号・頁	7,pp.151
著者・共著者	Hong Janet, Zhang Haijun, Kawase-Koga Yoko, Sun Tao
発行年月	2013
概要	The structure of the postnatal mammalian cerebral cortex is an assembly of numerous mature neurons that exhibit proper neurite outgrowth and axonal and dendritic morphology. While many protein coding genes are shown to be involved in neuronal maturation, the role of microRNAs (miRNAs) in this process is also becoming evident. We here report that blocking miRNA biogenesis in differentiated neurons results in microcephaly like phenotypes in the postnatal mouse brain. The smaller brain defect is not caused by defective neurogenesis, altered neuronal migration or significant neuronal cell death. Surprisingly, a dramatic increase in neuronal packing density within the postnatal brain is observed. Loss of miRNA function causes shorter neurite outgrowth and smaller soma size of mature neurons in vitro. Our results reveal the impact of miRNAs on normal development of neuronal morphology and brain function. Because neurite outgrowth is critical for neuroregeneration, our studies further highlight the importance of miRNAs in the treatment of neurological diseases.
DOI	10.3389/fncel.2013.00151
PMID	24062642