Yoko Kawase-Koga    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system.
Journal	Formal name：Developmental dynamics : an official publication of the American Association of Anatomists Abbreviation：Dev Dyn ISSN code：10970177/10588388
Domestic / Foregin	Foregin
Volume, Issue, Page	238(11),pp.2800-12
Author and coauthor	Kawase-Koga Yoko, Otaegi Gaizka, Sun Tao
Publication date	2009/11
Summary	MicroRNAs, processed by the RNAase III enzyme Dicer, are approximately 22 nucleotide endogenous noncoding small RNAs. The function of Dicer in the mouse central nervous system (CNS) development is not well understood. Here, we show that specifically deleting Dicer expression in the CNS and in the cerebral cortex using two Cre lines results in reduced progenitor numbers, abnormal neuronal differentiation, and thinner cortical wall. Incomplete Dicer deletion during early embryonic stages contributes to normal development of early-born neurons in the cortex and motor neurons in the spinal cord. However, at late embryonic stages when Dicer is completely ablated in the CNS, the migration of late-born neurons in the cortex and oligodendrocyte precursor expansion and differentiation in the spinal cord are greatly affected. Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development.
DOI	10.1002/dvdy.22109
PMID	19806666