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秋澤 叔香
Department School of Nursing, School of Nursing Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Possible Application of Ascites-infiltrating Gamma-delta T Cells for Adoptive Immunotherapy. |
| Journal | Formal name：Anticancer research Abbreviation：Anticancer Res ISSN code：17917530/02507005 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 38(7),pp.4327-4331 |
| Author and coauthor | Abe Yuki†, Kobayashi Hirohito*, Akizawa Yoshika, Ishitani Ken, Hashimoto Kazunori, Matsui Hideo |
| Publication date | 2018/07 |
| Summary | BACKGROUND/AIM:Malignant ascites contain many tumour-infiltrating lymphocytes. γδ T cells with antitumour activity have attracted attention as effector cells in cancer immunotherapy. Vδ2+ T cells were cultured from peripheral blood mononuclear cells (PBMCs) and ascites-infiltrating lymphocytes (AILs) to compare the differences in response to 2-methyl-3-butenyl-1-pyrophosphate (2M3B1-PP) and zoledronate (Zol) as antigens in vitro.MATERIALS AND METHODS:To expand Vδ2+ T cells from PBMCs and AILs from 29 patients with cancer, these cells were cultured and subjected to analysis.RESULTS:The proliferation rate of Vδ2+ T cells was higher in both PBMCs and AILs when cultured with Zol than with 2M3B1-PP. Although Vδ2+ T cells show a higher rate of expansion in AILs compared to PBMCs, the number of mixed tumour cells in ascites was decreased when cultured with Zol.CONCLUSION:Vδ2+ T cells in AILs are cytotoxic to tumour cells in ascites and may be considered in adoptive immunotherapy. |
| DOI | 10.21873/anticanres.12732 |
| PMID | 29970569 |