サエキ タダシロウ
  佐伯 忠賜朗
   所属   医学部 医学科(東京女子医科大学病院)
   職種   講師
論文種別 原著
言語種別 英語
査読の有無 査読あり
招待の有無 招待あり
表題 Elevated intraocular pressure, optic nerve atrophy, and impaired retinal development in ODAG transgenic mice.
掲載誌名 正式名:Investigative ophthalmology & visual science
略  称:Invest Ophthalmol Vis Sci
ISSNコード:(1552-5783)0146-0404(Linking)
掲載区分国外
巻・号・頁 50(1),242-8頁
著者・共著者 Sasaki Takaaki, Watanabe Wataru, Muranishi Yuki, Kanamoto Takashi, Aihara Makoto, Miyazaki Kazuko, Tamura Hiroki, Saeki Tadashiro, Oda Hideaki, Souchelnytskyi Nazariy, Souchelnytskyi Serhiy, Aoyama Hirohiko, Honda Zen-ichiro, Furukawa Takahisa, Mishima Hiromu K, Kiuchi Yoshiaki, Honda Hiroaki
発行年月 2009/01
概要 Deregulated expression of ODAG in the eye induces elevated intraocular pressure and optic nerve atrophy and impairs retinal development, possibly by interfering with the Rab6/Rab6-GAP-mediated signaling pathway. These results provide new insights into the mechanisms regulating ocular development, and ODAG Tg would be a novel animal model for human diseases caused by ocular hypertension.
DOI 10.1167/iovs.08-2206
PMID 18791169