Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position   Associate Professor (Fixed Term)
Article types Review article
Language English
Peer review Peer reviewed
Presence of invitation Invited paper
Title Current Landscape of Sonodynamic Therapy for Treating Cancer.
Journal Formal name:Cancers
Abbreviation:Cancers (Basel)
ISSN code:20726694/20726694
Domestic / ForeginForegin
Volume, Issue, Page 13(24),pp.6184
International coauthorship International coauthorship
Author and coauthor YAMAGUCHI Toshihiro†, KITAHARA Shuji, KUSUDA Kaori, OKAMOTO Jun, HORISE Yuki, MASAMUNE Ken, MURAGAKI Yoshihiro*
Authorship 2nd author
Publication date 2021/12/08
Summary Recent advancements have tangibly changed the cancer treatment landscape. However, curative therapy for this dreadful disease remains an unmet need. Sonodynamic therapy (SDT) is a minimally invasive anti-cancer therapy involving a chemical sonosensitizer and focused ultrasound. A high-intensity focused ultrasound (HIFU) beam is used to destroy or denature targeted cancer tissues. Some SDTs are based on unfocused ultrasound (US). In some SDTs, HIFU is combined with a drug, known as a chemical sonosensitizer, to amplify the drug's ability to damage cancer cells preferentially. The mechanism by which US interferes with cancer cell function is further amplified by applying acoustic sensitizers. Combining multiple chemical sonosensitizers with US creates a substantial synergistic effect that could effectively disrupt tumorigenic growth, induce cell death, and elicit an immune response. Therefore, the minimally invasive SDT treatment is currently attracting attention. It can be combined with targeted therapy (double-targeting cancer therapy) and immunotherapy in the future and is expected to be a boon for treating previously incurable cancers. In this paper, we will consider the current state of this therapy and discuss parts of our research.
DOI 10.3390/cancers13246184
PMID 34944804