キタハラ　シユウジ   KITAHARA Shuji   北原　秀治    所属   研究施設 研究施設    職種   特任准教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	Current Landscape of Sonodynamic Therapy for Treating Cancer.
掲載誌名	正式名：Cancers 略　 称：Cancers (Basel) ISSNコード：20726694/20726694
掲載区分	国外
巻・号・頁	13(24),pp.6184
国際共著	国際共著
著者・共著者	YAMAGUCHI Toshihiro†, KITAHARA Shuji, KUSUDA Kaori, OKAMOTO Jun, HORISE Yuki, MASAMUNE Ken, MURAGAKI Yoshihiro*
担当区分	2nd著者
発行年月	2021/12/08
概要	Recent advancements have tangibly changed the cancer treatment landscape. However, curative therapy for this dreadful disease remains an unmet need. Sonodynamic therapy (SDT) is a minimally invasive anti-cancer therapy involving a chemical sonosensitizer and focused ultrasound. A high-intensity focused ultrasound (HIFU) beam is used to destroy or denature targeted cancer tissues. Some SDTs are based on unfocused ultrasound (US). In some SDTs, HIFU is combined with a drug, known as a chemical sonosensitizer, to amplify the drug's ability to damage cancer cells preferentially. The mechanism by which US interferes with cancer cell function is further amplified by applying acoustic sensitizers. Combining multiple chemical sonosensitizers with US creates a substantial synergistic effect that could effectively disrupt tumorigenic growth, induce cell death, and elicit an immune response. Therefore, the minimally invasive SDT treatment is currently attracting attention. It can be combined with targeted therapy (double-targeting cancer therapy) and immunotherapy in the future and is expected to be a boon for treating previously incurable cancers. In this paper, we will consider the current state of this therapy and discuss parts of our research.
DOI	10.3390/cancers13246184
PMID	34944804