Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position   Associate Professor (Fixed Term)
Article types Original article
Language English
Peer review Peer reviewed
Title Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction.
Journal Formal name:Journal of immunology (Baltimore, Md. : 1950)
Abbreviation:J Immunol
ISSN code:15506606/00221767
Domestic / ForeginForegin
Volume, Issue, Page 190(11),pp.5609-19
Author and coauthor Shimizu Kanako, Asakura Miki, Shinga Jun, Sato Yusuke, Kitahara Shuji, Hoshino Katsuaki, Kaisho Tsuneyasu, Schoenberger Stephen P, Ezaki Taichi, Fujii Shin-ichiro
Publication date 2013/06
Summary A key goal of vaccine immunotherapy is the generation of long-term memory CD8(+) T cells capable of mediating immune surveillance. We discovered a novel intercellular pathway governing the development of potent memory CD8(+) T cell responses against cell-associated Ags that is mediated through cross-presentation by XCR1(+) dendritic cells (DCs). Generation of CD8(+) memory T cells against tumor cells pulsed with an invariant NKT cell ligand depended on cross-talk between XCR1(+) and plasmacytoid DCs that was regulated by IFN-α/IFN-αR signals. IFN-α production by plasmacytoid DCs was stimulated by an OX40 signal from the invariant NKT cells, as well as an HMGB1 signal from the dying tumor cells. These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8(+) memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy.
DOI 10.4049/jimmunol.1300033
PMID 23630347