KITAHARA Shiyuuji
Department Graduate School of Medical Science, Graduate School of Medical Science Position Associate Professor (Fixed Term) |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Invariant NKT cells induce plasmacytoid dendritic cell (DC) cross-talk with conventional DCs for efficient memory CD8+ T cell induction. |
Journal | Formal name:Journal of immunology (Baltimore, Md. : 1950) Abbreviation:J Immunol ISSN code:15506606/00221767 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 190(11),pp.5609-19 |
Author and coauthor | Shimizu Kanako, Asakura Miki, Shinga Jun, Sato Yusuke, Kitahara Shuji, Hoshino Katsuaki, Kaisho Tsuneyasu, Schoenberger Stephen P, Ezaki Taichi, Fujii Shin-ichiro |
Publication date | 2013/06 |
Summary | A key goal of vaccine immunotherapy is the generation of long-term memory CD8(+) T cells capable of mediating immune surveillance. We discovered a novel intercellular pathway governing the development of potent memory CD8(+) T cell responses against cell-associated Ags that is mediated through cross-presentation by XCR1(+) dendritic cells (DCs). Generation of CD8(+) memory T cells against tumor cells pulsed with an invariant NKT cell ligand depended on cross-talk between XCR1(+) and plasmacytoid DCs that was regulated by IFN-α/IFN-αR signals. IFN-α production by plasmacytoid DCs was stimulated by an OX40 signal from the invariant NKT cells, as well as an HMGB1 signal from the dying tumor cells. These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8(+) memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy. |
DOI | 10.4049/jimmunol.1300033 |
PMID | 23630347 |